Tell each of your health care providers about all medicines you. In human studies, 11% and 25% of the dose were recovered in urine and feces, respectively, as either parent drug or metabolite during the 5 day period following drug administration. Mitoxantrone also interferes with ribonucleic acid rna and is a potent inhibitor of topoisomerase ii, an enzyme responsible for uncoiling and repairing damaged dna. Although it is not licensed for ms in the uk, it is sometimes used in some specialist centres for people with highly active relapsing ms whose level of disability is developing. Nursing2018 drug handbook nursing drug handbook 38th edition pdf free download. Design of multifunctional magnetic iron oxide nanoparticles. The purpose of this study was to assess the effectiveness of mitoxantrone, a chemotherapeutic agent, as a. Phase iii study of gemcitabine plus mitoxantrone as. Mechanisms of action of mitoxantrone include intercalation with the dna molecule. Mitoxantrone must be given only by injection into a vein. Information from its description page there is shown below.
Mitoxantrone enhances tcell suppressor function and inhibits bcell function and antibody production. The results of in vitro induction studies are inconclusive, but suggest that mitoxantrone may be a weak inducer of cyp450 2e1 activity. Mitoxantrone concentrations are highest in the liver, bone marrow, heart, lung, kidney, blood components, pancreas, spleen, and thyroid. Unitedhealthcare group medicare advantage base plan. Management of worsening multiple sclerosis with mitoxantrone. These effects may be among the factors stimulating andor accompanying highdose mitoxantroneinduced.
Although maximally cytotoxic in the sphase, mitoxantrone. Jan 14, 2016 randomized, doubleblind, placebocontrolled, multicenter trial to test the efficacy of mitoxantrone 5mgm. Mitoxantrone should be administered into the tubing of a freely running intravenous infusion of 0. Use birth control that you can trust to prevent pregnancy while taking mitoxantrone. Mitoxantrone is administered as an intravenous infusion. Mitoxantrone novantrone package insert pdf page 3641 mitoxantrone novantrone patient drug information. Mitoxantrone fda prescribing information, side effects. It is used in combination with other chemotherapeutic agents to treat acute nonlymphocytic leukemia, hormonerefractory prostate cancer, breast cancer, lymphoma, and pediatric. In human studies, 11% and 25% of the dose were recovered in urine and feces, respectively, as either parent drug or metabolite during.
Until recently this combination was the first line of treatment. If you are pregnant or you get pregnant while taking mitoxantrone, call your doctor right away. Mitoxantrone novantrone is a simplified analog of the anthracyclines that has a complex mechanism of action. Identification of the substancemixture and of the companyundertaking. This agent also binds to topoisomerase ii, resulting in dna strand breaks and inhibition of dna repair. This article is from international journal of nanomedicine, volume 9. Mitoxantrone hydrochloride mitoxantrone hydrochloride. Mitoxantrone potently inhibits proliferation of b and t lymphocytes as well as macrophages. Study of mitoxantrone for the treatment of recurrent. This file contains additional information such as exif metadata which may have been added by the digital camera, scanner, or software program used to create or digitize it.
Mitoxantrone interferes with the growth of cancer cells, which are eventually destroyed. Pdf photodynamic therapy has the potential to become an effective alternate to surgery. Daviss drug guide for nurses pdf free download direct link. Mitoxantrone is a synthetic manmade anticancer drug. Mitoxantrone novantrone is an injection medication prescribed to treat ms, some forms of leukemia and pain with certain prostate cancer. Alright, now in this part of the article, you will be able to access the free pdf download of daviss drug guide for nurses pdf using our direct links mentioned at the end of this article. Mitoxantrone mitoxantrone dose, indications, adverse. Do not give by injection into a muscle, under the skin, or into the spinal cord.
The concentrate is a sterile, nonpyrogenic, dark blue aqueous. When administered to patients intravenously every three weeks, white blood cell wbc and platelet nadirs occurred between. Mitoxantrone, a dnareactive agent that intercalates into deoxyribonucleic acid dna through hydrogen bonding, causes crosslinks and strand breaks. In a cohort of mitoxantrone treated ms patients followed for varying periods of time, an elevated leukemia risk of. Unitedhealthcare group medicare advantage enhanced plan. Mitoxantrone hydrochloride safety data sheet supersedes revision. Nov 18, 2012 mitoxantrone is a dihydroxyanthracenedione derivative which as intravenous mono and combination therapy has demonstrated therapeutic efficacy similar to that of standard induction and salvage treatment regimens in advanced breast cancer, non hodgkins lymphoma, acute nonlymphoblastic leukaemia and chronic myelogenous leukaemia in blast crisis. Mitoxantrone is an anthracenedione antibiotic with antineoplastic activity.
Nov 21, 2019 what other drugs will affect mitoxantrone novantrone. To download the pdf, click the download link below. Mitoxantrone hydrochloride is the common name for the dihydrochloride salt. Mitoxantrone hydrochloride is approved to be used with other drugs to treat. Mitoxantrone is excreted in urine and feces as either unchanged drug or as inactive metabolites. In animal tumor models, it was equally cytotoxic as but less cardiotoxic than the parent compounds. Mitoxantrone is also used to treat multiple sclerosis ms, most notably the subset of the disease known as secondaryprogressive ms. Daunorubicin versus mitoxantrone versus idarubicin as. It belongs to the group of medicines known as antineoplastics or cancer medicines.
Mitoxantrone is a cancer medication that interferes with the growth and spread of cancer cells in the body. Mitoxantrone hydrochloride mitoxantrone hydrochloride pfizer. Novantrone mitoxantrone for injection concentrate warning novantrone mitoxantrone for injection concentrate should be administered under the supervision of a physician experienced in the use of cytotoxic chemotherapy agents. Studies on the binding affinity of anticancer drug mitoxantrone to. Other drugs may interact with mitoxantrone, including prescription and overthecounter medicines, vitamins, and herbal products. Mitoxantrone is also used to treat some forms of multiple sclerosis ms. If this medication accidentally leaks into the skin. Mec mitoxantrone, etoposide, and cytarabine induces. At this dose, % of patients have moderate to severe decreases in. Adobe acrobat reader dc software is the free global standard for reliably viewing, printing, and commenting on pdf documents. Since the growth of normal body cells may also be affected by mitoxantrone, other unwanted effects will. Pdf mitoxantrone as a prospective photosensitizer for. Novantrone mitoxantrone for injection concentrate is an intravenously delivered synthetic molecule for the treatment of multiple sclerosis ms.
Dec 24, 2019 you may need to have a pregnancy test while taking mitoxantrone. Excretion and metabolism of mitoxantrone in rabbits article pdf available in cancer research 494. Pdf excretion and metabolism of mitoxantrone in rabbits. Although it is not licensed for ms in the uk, it is sometimes used in some specialist centres for people with highly active relapsing ms whose level of disability is developing rapidly.
Mitoxantrone is an anthracenedione, a related drug the occurrence of refractory secondary leukemia is more common when anthracyclines are given in combination with dnadamaging antineoplastic agents, when patients have been heavily pretreated with cytotoxic drugs. Mitoxantrone injection comes as a liquid to be given intravenously into a vein by a doctor or nurse in a hospital or clinic. This file is licensed under the creative commons attributionshare alike 4. Mitoxantrone is the generic form of the brand name drug novantrone, which is an injection used to treat certain types of multiple sclerosis. If you are 65 or older, use mitoxantrone with care. Multiple sclerosis mitoxantrone is indicated for reducing neurologic disability andor the frequency of clinical relapses in. No drug interactions with other highly protein bound drugs have been recognized. Additional doses of mitoxantrone should not be administered to multiple sclerosis patients who have experienced either a drop in lvef to below the lower limit of. Mitoxantrone injection is used alone or together with other medicines to treat advanced prostate cancer and acute nonlymphocytic leukemia anll. Mitoxantrone is a chemotherapy drug that is sometimes used in ms as a disease modifying drug dmd to reduce the number of relapses a person is experiencing. Mitoxantrone novantrone, an antineoplastic agent with profound immunosuppressive effects, is chemically related to the anthracyclines such as doxorubicin and acts as a potent immunosuppressive agent for treatment of ms. Previous studies have reported partially effective therapies. All structured data from the file and property namespaces is available under the creative commons cc0 license. Study evaluating mitoxantrone in multiple sclerosis full.
And now, its connected to the adobe document cloud. We here describe the clinical course of a 9year old girl who inadvertently received 100 mgm2 of mitoxantrone as a bolus injection. Mitoxantrone is only found in individuals that have used or taken this drug. It also interferes with ribonucleic acid rna and inhibits the activity of topoisomerase ii, an enzyme that is necessary for repairing damaged dna. Novantrone mitoxantrone hydrochloride is a synthetic antineoplastic anthracenedione for intravenous use. Mitoxantrone and analogues bind and stabilize imotif. Mitoxantrone is a cytotoxic drug used in the treatment of malignant disease in humans and animals.
Use of some vaccines with mitoxantrone may either raise the chance of an infection or make the vaccine not work as well. Sep 05, 2005 study evaluating mitoxantrone in multiple sclerosis the safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Mitoxantrone in combination with other approved drugs is indicated in the initial therapy of anll in adults. Mitoxantrone is a dihydroxyanthracenedione derivative which as intravenous mono and combination therapy has demonstrated therapeutic efficacy similar to that of standard induction and salvage treatment regimens in advanced breast cancer, non hodgkins lymphoma, acute nonlymphoblastic leukaemia and chronic myelogenous leukaemia in blast crisis. Mitoxantrone is an anthraquinone structurally related to the anthracycline drugs doxorubicin and daunorubicin.
Mitoxantrone hydrochloride national cancer institute. It acts in ms by suppressing the activity of t cells, b cells, and macrophages that are thought to lead the attack on the myelin sheath. For patients taking mitoxantrone to treat ms multiple sclerosis. Reversible cardiopathy after accidental overdose of.
Quantitative confocal spectral imaging analysis of mitoxantrone. Is there a new place for mitoxantrone in the treatment of. The injection solution may also contain acetic acid, sodium acetate, sodium chloride, sodium. The product catalog provides you with a full listing of tevas brand and generic product lines. This medicine is used to treat acute nonlymphocytic leukemia and advanced prostate cancer. When mitoxantrone injection is used to treat ms, it is usually given once every 3 months for about 2 to 3 years for a total of 8 to 12 doses. Compared with interferon betas, mitoxantrone has a broad range of actions and has effects on many different types of immune cells. Read this medication guide before you start receiving mitoxantrone and each. Files are available under licenses specified on their description page. It impairs antigen presentation and decreases the secretion of proinflammatory cytokines. Novantrone is a cytotoxic agent that produces dosedependent myelosuppression.
Study evaluating mitoxantrone in multiple sclerosis the safety and scientific validity of this study is the responsibility of the study sponsor and investigators. In march 2005, the labeling for mitoxantrone was changed to recommend that left ventricular ejection fraction lvef be evaluated before initiating treatment and prior to. Mitoxantrone intercalates into dna causing crosslinking and strand breaks, interferes with rna, and is an inhibitor of topoisomerase ii. Mitoxantrone hydrochloride marketed as novantrone and. Novantrone mitoxantrone for injection concentrate fda. Side effects, drug interactions, dosage, and pregnancy safety information is included. Jul 17, 2015 in march 2005, the labeling for mitoxantrone was changed to recommend that left ventricular ejection fraction lvef be evaluated before initiating treatment and prior to administering each dose.
The pdf file you selected should load here if your web browser has a pdf reader plugin installed for example, a recent version of adobe acrobat reader. Mitoxantrone is used to treat certain types of cancer, mostly acute myeloid leukemia. When administered to patients intravenously every three weeks, white blood cell wbc and platelet nadirs occurred between days 8. Dailymed mitoxantrone injection, solution, concentrate.
Mitoxantrone information, side effects, warnings and recalls. Abstract tumortargeting multifunctional liposomes simultaneously loaded with magnetic iron oxide nanoparticles mions as a magnetic resonance imaging mri contrast agent and anticancer drug, mitoxantrone mit, were developed for targeted cancer therapy and ultrasensitive mri. This page was last edited on 14 september 2009, at 10. In the absence of a cure, mitoxantrone is effective in slowing the progression of secondaryprogressive ms and extending the time between relapses in both relapsingremitting ms and progressiverelapsing ms. Pharmacokinetic studies of the interaction of novantrone with concomitantly. Mitoxantrone intercalates into and crosslinks dna, thereby disrupting dna and rna replication. The recommended maximum cumulative dose of mitoxantrone is 140 mgm2.
Pdf the conclusions of a recent study of mitoxantrone novantrone in. Mitoxantrone hydrochloride mitoxantrone hydrochloride this product information is intended only for residents of the united states. This sds was prepared in accordance with 29 cfr 1910. Mitoxantrone by injection national library of medicine. Listing a study does not mean it has been evaluated by the u. Alternatively, you can also download the pdf file directly to your computer, from where it can be opened using a pdf reader. First clinical studies of mitoxantrone in multiple sclerosis. For example, it suppresses the proliferation of t cells, b cells, and macrophages. It kills cancer cells by disrupting the action of deoxyribonucleic acids dna in human cells by causing abnormal crosslinks and breaks in the dna. If possible, avoid veins over joints or in extremities with. Mitoxantrone novantrone, is an anthracenedione which in preclinical studies demonstrated a spectrum of antitumor activity similar to the anthracyclines, but with less cardiotoxicity. It is also used to treat certain types of multiple sclerosis. When mitoxantrone injection is used to treat prostate cancer, it is usually. Dec 28, 2004 mitoxantrone is effective in reducing disease progression through a variety of different mechanisms of action.
Serono inc, rockland, mass is an anthracenedione antineoplastic agent approved by the us food and drug administration as a treatment for secondary progressive and worsening relapsingremitting ms. Mitoxantrone fda prescribing information, side effects and uses. Download pdf introduction imotifs are quadruplex dna secondary structures formed from cytosinerich sequences and stabilised by intercalated. Mitoxantrone also interferes with ribonucleic acid rna and is a potent inhibitor of topoisomerase ii, an enzyme. Medication guide mitoxantrone mitoxantrone for injection concentrate. What other drugs will affect mitoxantrone novantrone. This category includes myelogenous, promyelocytic, monocytic, and erythroid acute leukemias.
Novantrone belongs to the general group of medicines called antineoplastics. Finally, it inhibits macrophagemediated myelin degradation. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using. The tubing should be attached to a butterfly needle or other suitable device and inserted preferably into a large vein. To compare the clinical and neuroradiological efficacy of mitoxantrone mtx in various forms of multiple sclerosis ms, to ascertain whether there is a new place for the drug in the treatment regimen of the disease, as well as to determine its safety profile.
It is used as palliative treatment in patients with advanced disease that is hormonerefractory does not respond to hormone treatment. It is an anthracenedionederived antineoplastic agent. If the file has been modified from its original state, some details such as the timestamp may not fully reflect those of the original file. Mitoxantrone prices and mitoxantrone coupons goodrx. Mitoxantrone is less cardiotoxic compared to doxorubicin. Mitoxantrone is an anthracenedione, a related drug the occurrence of refractory secondary leukemia is more common when anthracyclines are given in combination with dnadamaging antineoplastic agents, when patients have been heavily pretreated with cytotoxic drugs, or when doses of anthracyclines have been escalated. Wed like to understand how you use our websites in order to improve them. The catalog displays all strengths and sizes along with the description, imprint code, ndc and photo for each product. Mechanisms of action of mitoxantrone include intercalation with the dna molecule, which in turn causes single and double. Request pdf on mar 7, 2020, giovanni marconi and others published mec mitoxantrone, etoposide, and cytarabine induces complete remission and is an effective bridge to transplant in acute. The purpose of this study was to determine the maximumtolerated dose of gemcitabine plus mitoxantrone in women with metastatic breast cancer mbc and to.
It improves the survival rate of children suffering from acute lymphoblastic leukemia relapse the combination of mitoxantrone and prednisone is approved as a secondline treatment for metastatic hormonerefractory prostate cancer. Prior to its approval for use in ms, it was used only to treat certain forms of cancer. It is supplied as a concentrate that must be diluted prior to injection. Novantrone mitoxantrone for injection concentrate side.
463 1483 652 163 624 668 1082 58 836 1217 1557 913 772 1507 159 442 1231 1044 134 435 1311 1563 794 955 29 1540 840 346 1300 1310 570 52 124 382 166 692 690 86 565 1329 754